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Ionis Pharmaceuticals

55.65

-0.3700-0.66%

Pre-market: 55.05-0.6000-1.08%06:00 EDT

Volume:3.06M

Turnover:169.31M

Market Cap:9.25B

PE:-15.99

High:55.77

Open:55.75

Low:54.91

Close:56.02

52wk High:86.74

52wk Low:50.01

Shares:166.18M

Float Shares:161.92M

Volume Ratio:0.73

T/O Rate:1.89%

Dividend:- -

Dividend Rate:- -

EPS(TTM):-3.4800

EPS(LYR):-2.3812

ROE:-105.50%

ROA:-12.42%

PB:21.03

PE(LYR):-23.37

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Overview Company News Filings

BofA Adjusts Price Target on Ionis Pharmaceuticals to $91 From $93

MT Newswires Live

Bank of America Securities Keeps Their Buy Rating on Ionis Pharmaceuticals (IONS)

U.S. Stocks on the MOVE-Best Buy, Peloton, Apple

Ionis Pharmaceuticals price target lowered to $84 from $87 at Raymond James

Royalty Pharma Falls After Novartis' Cholesterol Drug Fails in Study

U.S. Stocks on the MOVE-Sigma Lithium, Shake Shack, Novartis

Movement Alert｜Ionis Pharmaceuticals Falls 7.76% in Regular Trading, Partner Novartis Lp(a) Drug Fails Phase 3 Trial

Ionis Pharmaceuticals price target lowered to $104 from $110 at Morgan Stanley

Ionis Pharmaceuticals, Inc. : TD Cowen Cuts Target Price to $84 from $94

THOMSON REUTERS

Canaccord Genuity Sticks to Its Buy Rating for Ionis Pharmaceuticals (IONS)

Ionis Pharmaceuticals Price Target Cut to $100.00/Share from $115.00 by HC Wainwright & Co.

Analysts Offer Insights on Healthcare Companies: Dyne Therapeutics (DYN), NewAmsterdam Pharma Company (NAMS) and Ionis Pharmaceuticals (IONS)

Movement Alert｜Ionis Pharmaceuticals Falls 12.19% in Pre-Market Trading, Partner Novartis Lp(a) Drug Pelacarsen Fails Phase 3 Cardiovascular Outcomes Trial

Ionis Pharmaceuticals price target lowered to $56 from $69 at Goldman Sachs

Ionis Pharma Shares Down 13.1% Premarket After Co's Heart Drug Fails Late-Stage Trial

THOMSON REUTERS

Ionis Pharma Tumbles After Heart Drug Fails Late-Stage Trial

Movement Alert｜Ionis Pharmaceuticals Falls 9.78% Overnight, Partner Novartis Pelacarsen Phase 3 Cardiovascular Outcomes Trial Fails to Meet Primary Endpoint

Citi sees limited immediate downside for Ionis after pelacarsen failure

Stocks to Watch: Ionis Pharmaceuticals, Novartis, Corvex

Ionis Pharmaceuticals Updates on Novartis Pelacarsen Trial Outcome

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A missed opportunity, but the growth outlook is little changed\" - Royalty Pharma** RPRX reiterates \"its 2030 Portfolio Receipts target of $4.7 billion or more\"** Including session's move, stock up 54.7% 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The decline was driven by news that partner Novartis...","market":"hk","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":"Novartis Lp(a) Drug Fails Phase 3, Ionis Tumbles","news_tag":"productRelease","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665235378","title":"Ionis Pharmaceuticals price target lowered to $104 from $110 at Morgan Stanley","url":"https://stock-news.laohu8.com/highlight/detail?id=2665235378","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665235378?lang=en_us&edition=fundamental","pubTime":"2026-09-08 20:36","pubTimestamp":1788870980,"startTime":"0","endTime":"0","summary":"Morgan Stanley analyst Michael Ulz lowered the firm’s price target on Ionis Pharmaceuticals (IONS) to $104 from $110 and keeps an Overweight rating...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/ionis-pharmaceuticals-price-target-lowered-to-104-from-110-at-morgan-stanley-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/ionis-pharmaceuticals-price-target-lowered-to-104-from-110-at-morgan-stanley-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665320244","title":"Ionis Pharmaceuticals, Inc. : TD Cowen Cuts Target Price to $84 from $94","url":"https://stock-news.laohu8.com/highlight/detail?id=2665320244","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665320244?lang=en_us&edition=fundamental","pubTime":"2026-09-08 20:18","pubTimestamp":1788869913,"startTime":"0","endTime":"0","summary":null,"market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260908:nFWN4500I3:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["IONS","BK4139"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665437327","title":"Canaccord Genuity Sticks to Its Buy Rating for Ionis Pharmaceuticals (IONS)","url":"https://stock-news.laohu8.com/highlight/detail?id=2665437327","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665437327?lang=en_us&edition=fundamental","pubTime":"2026-09-08 19:35","pubTimestamp":1788867323,"startTime":"0","endTime":"0","summary":"In a report released today, Gary Nachman from Canaccord Genuity maintained a Buy rating on Ionis Pharmaceuticals, with a price target of $85.00. Na...","market":"fut","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/blurbs/canaccord-genuity-sticks-to-its-buy-rating-for-ionis-pharmaceuticals-ions-blurbs-news-2?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/blurbs/canaccord-genuity-sticks-to-its-buy-rating-for-ionis-pharmaceuticals-ions-blurbs-news-2?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665275393","title":"Ionis Pharmaceuticals Price Target Cut to $100.00/Share from $115.00 by HC Wainwright & Co.","url":"https://stock-news.laohu8.com/highlight/detail?id=2665275393","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665275393?lang=en_us&edition=fundamental","pubTime":"2026-09-08 19:28","pubTimestamp":1788866880,"startTime":"0","endTime":"0","summary":"Ratings actions from Benzinga: https://www.benzinga.com/quote/IONS/analyst-ratings","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665232230","title":"Analysts Offer Insights on Healthcare Companies: Dyne Therapeutics (DYN), 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Alert｜Ionis Pharmaceuticals Falls 12.19% in Pre-Market Trading, Partner Novartis Lp(a) Drug Pelacarsen Fails Phase 3 Cardiovascular Outcomes Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=1165504833","media":"Market Focus","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1165504833?lang=en_us&edition=fundamental","pubTime":"2026-09-08 18:45","pubTimestamp":1788864311,"startTime":"0","endTime":"0","summary":"On September 8, Ionis Pharmaceuticals fell 12.19% in pre-market trading, trading at $50.95/share, with turnover of $4.99 million.On the news front, partner Novartis announced on September 4 that...","market":"hk","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":"Ionis Tumbles as Novartis Pelacarsen Fails Phase 3 Trial","news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665324158","title":"Ionis Pharmaceuticals price target lowered to $56 from $69 at Goldman Sachs","url":"https://stock-news.laohu8.com/highlight/detail?id=2665324158","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665324158?lang=en_us&edition=fundamental","pubTime":"2026-09-08 18:35","pubTimestamp":1788863723,"startTime":"0","endTime":"0","summary":"Goldman Sachs lowered the firm’s price target on Ionis Pharmaceuticals (IONS) to $56 from $69 and keeps a Neutral rating on the shares. The pelacar...","market":"us","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/ionis-pharmaceuticals-price-target-lowered-to-56-from-69-at-goldman-sachs-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":["rate"],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/ionis-pharmaceuticals-price-target-lowered-to-56-from-69-at-goldman-sachs-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-1","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665732457","title":"Ionis Pharma Shares Down 13.1% Premarket After Co's Heart Drug Fails Late-Stage Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2665732457","media":"THOMSON REUTERS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665732457?lang=en_us&edition=fundamental","pubTime":"2026-09-08 18:32","pubTimestamp":1788863565,"startTime":"0","endTime":"0","summary":null,"market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260908:nL4N4500QY:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"reuters_en_live","symbols":["BK4139","IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665839324","title":"Ionis Pharma Tumbles After Heart Drug Fails Late-Stage Trial","url":"https://stock-news.laohu8.com/highlight/detail?id=2665839324","media":"Reuters","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665839324?lang=en_us&edition=fundamental","pubTime":"2026-09-08 18:22","pubTimestamp":1788862967,"startTime":"0","endTime":"0","summary":"BUZZ-Ionis Pharma tumbles after heart drug fails late-stage trial** Ionis Pharmaceuticals'IONS.Oshares fall 12.7% to $50.70 premarket** NovartisNOVN.Sand Ionis said late Friday their experimental drug pelacarsendid not cutthe risk of major heart attacks and strokes in patients with a genetic risk factor in a late-stage trial** The drug successfully lowered a dangerous genetic cholesterol, Lp, but it did not improve overall heart health outcomes** The trial failure was negative for biopharma sector perception because lowering Lp \"did not reduce cardiovascular events in the overall population\", say analysts at Leerink Partners**Amgen'sAMGN.Oand Eli Lilly'sLLY.Ndrugs \"lower Lp more than pelacarsen\" and could now facegreater scrutiny- brokerage** Amgen shares slip 5% to $415.01 before the bell** As of last close, IONS down 26.6% YTD","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://api.refinitiv.com/data/news/v1/stories/urn:newsml:reuters.com:20260908:nL4N4500PU:1","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":null,"news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["BK4139","LU1571399168.USD","IE0009355771.USD","LU0320765992.SGD","IE00B2B36J28.USD","LU0109394709.USD","SG9999001440.SGD","BK4588","BK4534","BK4566","LU0868494617.USD","LU0058720904.USD","LU1983299246.USD","BK4533","IE0002141913.USD","LU2242652126.USD","BK4585","BBH","IE00B4R5TH58.HKD","IE00BJT1NW94.SGD","LU0122379950.USD","LU1023059063.AUD","IONS","LU1057294990.SGD","TBXU","LU0289739699.SGD","04332","BIB","LU0889565916.HKD","IE00BJJMRZ35.SGD","IBBQ","PJP","LU1061106388.HKD","LU2089984988.USD","LU2112291526.USD","BK4599","LU2242646821.SGD","AMGN","BK4581","LU2468319806.SGD","IBB","PBE","IE00BFTCPJ56.SGD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"1170767998","title":"Movement Alert｜Ionis Pharmaceuticals Falls 9.78% Overnight, Partner Novartis Pelacarsen Phase 3 Cardiovascular Outcomes Trial Fails to Meet Primary Endpoint","url":"https://stock-news.laohu8.com/highlight/detail?id=1170767998","media":"Market Focus","labels":["dataReport"],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/1170767998?lang=en_us&edition=fundamental","pubTime":"2026-09-08 08:21","pubTimestamp":1788826911,"startTime":"0","endTime":"0","summary":"On September 8, Ionis Pharmaceuticals fell 9.78% overnight, trading at $52.41/share, with turnover of $57,300. The decline was triggered by partner Novartis announcing on September 4 that pelacarsen,...","market":"hk","thumbnail":"","type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"-2","news_top_title":"Novartis Pelacarsen Phase 3 Failure Sinks Ionis","news_tag":"dataReport","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["IONS"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665552317","title":"Citi sees limited immediate downside for Ionis after pelacarsen failure","url":"https://stock-news.laohu8.com/highlight/detail?id=2665552317","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665552317?lang=en_us&edition=fundamental","pubTime":"2026-09-07 23:15","pubTimestamp":1788794109,"startTime":"0","endTime":"0","summary":"After Ionis’ (IONS) partner Novartis (NVS) disclosed that the pelacarsen Phase 3 Lp(a)HORIZON study failed to meet its primary endpoint of cardiova...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/the-fly/citi-sees-limited-immediate-downside-for-ionis-after-pelacarsen-failure-thefly-news?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/the-fly/citi-sees-limited-immediate-downside-for-ionis-after-pelacarsen-failure-thefly-news?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["LU0211331839.USD","BK4588","NVS","BK4007","PPH","IE00BJT1NW94.SGD","IE00BJJMRZ35.SGD","IE00BFTCPJ56.SGD","LU0070302665.USD","IONS","MEDX","IE00B2B36J28.USD","LU0208291251.USD","IE00B4R5TH58.HKD","IE0009355771.USD","BK4139","IE0002141913.USD","BK4585","BK4532","BK4578","LU0320765489.SGD"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665352693","title":"Stocks to Watch: Ionis Pharmaceuticals, Novartis, Corvex","url":"https://stock-news.laohu8.com/highlight/detail?id=2665352693","media":"Dow Jones","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665352693?lang=en_us&edition=fundamental","pubTime":"2026-09-05 06:58","pubTimestamp":1788562680,"startTime":"0","endTime":"0","summary":"A heart disease drug made by Ionis Pharmaceuticals and Novartis didn't meet its primary endpoint in a Phase 3 trial. Ionis shares slid 9.5% to $52.60 in after-hours trading on Friday, while Novartis shares were off 4.4% at $153.04.Corvex said it had a loss of $26.3 million in the first half of the year. The stock fell 7.5% to $13.63 after the bell.","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":null,"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://dowjonesnews.com/newdjn/logon.aspx?AL=N","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":null,"symbols":["MOVE","BK4170","BK4585","IE0002141913.USD","BK4139","IE00BJT1NW94.SGD","IE00B4R5TH58.HKD","LU0320765489.SGD","PPH","LU0211331839.USD","NVS","IE00BFTCPJ56.SGD","IE0009355771.USD","BK4532","IONS","MEDX","BK4007","IE00B2B36J28.USD","LU0070302665.USD","IE00BJJMRZ35.SGD","LU0208291251.USD","BK4588","BK4578"],"isVideo":false,"video":null,"gpt_icon":0},{"id":"2665354295","title":"Ionis Pharmaceuticals Updates on Novartis Pelacarsen Trial Outcome","url":"https://stock-news.laohu8.com/highlight/detail?id=2665354295","media":"TIPRANKS","labels":[],"top":-1,"itemType":null,"share":"https://ttm.financial/m/news/2665354295?lang=en_us&edition=fundamental","pubTime":"2026-09-05 05:47","pubTimestamp":1788558478,"startTime":"0","endTime":"0","summary":"Ionis Pharmaceuticals ( ($IONS) ) has shared an announcement. On September 4, 2026, Ionis Pharmaceuticals reported that its partner Novartis’ Phase...","market":"nz","thumbnail":null,"type":0,"news_type":0,"thumbnails":[],"rights":{"source":"tipranks_highlight","url":"https://www.tipranks.com/news/company-announcements/ionis-pharmaceuticals-updates-on-novartis-pelacarsen-trial-outcome?utm_source=itigerup.com&utm_medium=referral","rn_cache_url":null,"directOrigin":true},"property":[],"language":"en","translate_title":"","themeId":null,"theme_name":"","theme_type":"","isJumpTheme":false,"source_url":"https://www.tipranks.com/news/company-announcements/ionis-pharmaceuticals-updates-on-novartis-pelacarsen-trial-outcome?utm_source=itigerup.com&utm_medium=referral","is_publish_highlight":false,"source_rank":0,"column":"","sentiment":"0","news_top_title":null,"news_tag":"","news_rank":0,"length":0,"strategy_id":0,"source":"tipranks_highlight","symbols":["IONS","BK4139"],"isVideo":false,"video":null,"gpt_icon":0}],"pageSize":20,"totalPage":10,"pageCount":1,"totalSize":200,"code":"91000000","status":"200"}]}}